Exploring 3D Space

Dial-a-Molecule Theme 3 Synthesis College

Synthetic Tools for the Exploration of 3D Pharmaceutical Space


When: Friday 17th November 2017

Where: University of York


This free-to-attend meeting brought together 80 researchers at all career stages, from industry and academia, to learn about and discuss recent developments in the synthesis, analysis and biological evaluation of 3D molecules and their pharmaceutical importance.

The program of talks and activities comprised:

Session 1: Chaired by Dr Will Unsworth (University of York)

10.30–11.00. Prof Joe Sweeney (University of Huddersfield) Title tbc

11.00–12.15. Industry/academia collaboration mini-session. Four short talks by academics who have established successful industry/academia collaborations connected to 3D pharmaceutical space. Followed by a 15 minute Q+A session for all speakers.

  • Prof Rob Stockman (University of Nottingham).
    • European Lead Factory – an Industry/academic Partnership in Drug Discovery
  • Dr Liam Cox (University of Birmingham).
    • Innovative Training Network European Industrial Doctorate Training Programmes: EU Funding Opportunities post Brexit?
  • Prof. Peter O’Brien (University of York).
    • Fragment-Based Drug Discovery in 3-D: Academia meets Industry.
  • Prof. Nigel Simpkins (University of Birmingham).
    • Challenges and Opportunities for 3D scaffold chemistry in pharmaceutical R&D

12.15–13.30. Lunch, including poster session. Exhibitions from Advion, Fluorochem and Radleys and a live demonstration of LLAMA (Dr James Firth, York).

Session 2: Chaired by Dr Paul Clarke (University of York)

  • 13.30–13.55 Dr Susannah Coote (Lancaster University)
    • Outside the box: Synthesis of new Cubane Dervatives
  • 13.55–14.20 Dr James Bull (Imperial College London)
    • Synthesis of N-Heterocycles as 3-D Fragments: Strategies for a Faster Escape from Flatland
  • 14.20–14.45 Dr Jeff St Denis (Astex)
    • The Influence of Size and Shape in Fragment-Based Drug Discovery
  • 14.45–15.10 Dr Rob Young (GSK)
    • Why Pharma needs tools to explore 3D space; the pitfalls of flatness (and fatness)

15.10–15.45 Coffee/posters

Session 3: Chaired by Prof. Peter O’Brien (University of York)

  • 15.45–16.10 Dr Elaine O’Reilly (University of Nottingham)
    • Biocatalytic strategies for chiral amine synthesis
  • 16.10–17.10 Prof Erick Carreira (ETH Zurich)
    • Recent Developments in Strategies and Tactics Towards Complex Secondary Metabolites as enabling tools for the Study of Natural Products Biology

17.10 Drinks reception, then close.

A meeting report may be downloaded:  DaM 3D meeting report 3-POB