Closed Loop Optimisation of Synthesis

Closed Loop Optimisation of Synthesis

16 April 2015
GSK Stevenage

The optimisation of of synthetic procedures is a time-consuming process which is rarely carried out as efficiently as would be desirable. Automated reaction equipment, and in-line/in-situ analytical tools are becoming more readily available, but these still require the chemist to set-up reactions, analyse the outcomes, and decide which experiment(s) to do next.

In addition to keynote presentations, the day will also include:

  • progress from the Dial-a-Molecule inspired “Manufacturing the Future – Closed Loop Optimisation” team
  • the opportunity to showcase your own research in an interactive flash poster session
  • an exhibition from key suppliers
  • a lively panel discussion to debate the merits of Closed Loop Optimisation

Meeting report: Download here

Program: Also available as a PDF download here


09:00 Registration and coffee
09:30 Welcome and Introduction
Dr Robin Attrill (GSK)
09:45 Opportunities for closed loop optimisation with the pharmaceutical industry
Mr Andrew Richards (GSK)
10:05 Automated optimisation in continuous flow
Dr Richard Bourne (University of Leeds)
10:50 Coffee and exhibition
11:10 Manufacturing the future: Closed loop optimisation for sustainable chemical manufacture
Closed loop optimisation of continuous processes using HPLC Monitoring; Prof Richard Whitby (University of SouthamptonSequential optimisation of semi-batch reactions for discovery of process recipes; Prof Alexei Lapkin (University of Cambridge)

Multivariate analysis of reaction data; Dr Alison Nordon (University of Strathclyde)

Statistical challenges for automatic experimentation; Prof Dave Woods (University of Southampton)

12:15 Flash poster presentations
12:45 Lunch, exhibition and poster session
13:45 Self-optimising and other reactions
Prof Martyn Poliakoff (University of Nottingham)
14:30 Closed loop optimisation using non-linear regression analysis
Mr Chris Selway (Cyclofluidic)
14:50 Control of novel continuous reactors in flexible manufacturing
Dr Ewan Mercer (Perceptive Engineering)
15:10 Afternoon refreshments and exhibition
15:30 Optimal control of chemical reactions with data-driven models
Dr Frank Langbein (Cardiff University)
15:50 Using configurable robotics, algorithms and randomness to discover and synthesise new molecules
Prof Lee Cronin (Univerisity of Glasgow)
16:35 Panel discussion
17:15 Poster session and wine reception

Exhibiting Companies:  Advion, Amigo Chem, Cambridge Reactor Design, Gilson, HEL Group, JMP, Mettler Toledo, Radleys, Syrris, Uniqsis, Vaprourtec

Organising Committee:  Richard Whitby, Robin Attrill, Andrew Richards & Gill Smith