Closed Loop Optimisation of Synthesis
16 April 2015
at
GSK Stevenage
The optimisation of of synthetic procedures is a time-consuming process which is rarely carried out as efficiently as would be desirable. Automated reaction equipment, and in-line/in-situ analytical tools are becoming more readily available, but these still require the chemist to set-up reactions, analyse the outcomes, and decide which experiment(s) to do next.
In addition to keynote presentations, the day will also include:
- progress from the Dial-a-Molecule inspired “Manufacturing the Future – Closed Loop Optimisation” team
- the opportunity to showcase your own research in an interactive flash poster session
- an exhibition from key suppliers
- a lively panel discussion to debate the merits of Closed Loop Optimisation
Meeting report: Download here
Program: Also available as a PDF download here
| 09:00 | Registration and coffee |
| 09:30 | Welcome and Introduction |
| Dr Robin Attrill (GSK) | |
| 09:45 | Opportunities for closed loop optimisation with the pharmaceutical industry |
| Mr Andrew Richards (GSK) | |
| 10:05 | Automated optimisation in continuous flow |
| Dr Richard Bourne (University of Leeds) | |
| 10:50 | Coffee and exhibition |
| 11:10 | Manufacturing the future: Closed loop optimisation for sustainable chemical manufacture |
| Closed loop optimisation of continuous processes using HPLC Monitoring; Prof Richard Whitby (University of SouthamptonSequential optimisation of semi-batch reactions for discovery of process recipes; Prof Alexei Lapkin (University of Cambridge)
Multivariate analysis of reaction data; Dr Alison Nordon (University of Strathclyde) Statistical challenges for automatic experimentation; Prof Dave Woods (University of Southampton) |
|
| 12:15 | Flash poster presentations |
| 12:45 | Lunch, exhibition and poster session |
| 13:45 | Self-optimising and other reactions |
| Prof Martyn Poliakoff (University of Nottingham) | |
| 14:30 | Closed loop optimisation using non-linear regression analysis |
| Mr Chris Selway (Cyclofluidic) | |
| 14:50 | Control of novel continuous reactors in flexible manufacturing |
| Dr Ewan Mercer (Perceptive Engineering) | |
| 15:10 | Afternoon refreshments and exhibition |
| 15:30 | Optimal control of chemical reactions with data-driven models |
| Dr Frank Langbein (Cardiff University) | |
| 15:50 | Using configurable robotics, algorithms and randomness to discover and synthesise new molecules |
| Prof Lee Cronin (Univerisity of Glasgow) | |
| 16:35 | Panel discussion |
| 17:15 | Poster session and wine reception |
Exhibiting Companies: Advion, Amigo Chem, Cambridge Reactor Design, Gilson, HEL Group, JMP, Mettler Toledo, Radleys, Syrris, Uniqsis, Vaprourtec
Organising Committee: Richard Whitby, Robin Attrill, Andrew Richards & Gill Smith
