Alzheimer’s Society funded PhD Studentship – Investigating the role of tauopathy-induced activating transcription factor 3: a transcriptional hub to modulate neurodegeneration.
Fully funded PhD position available to study the role of ATF3 in tau-mediated neurodegeneration. We have previously identified an upregulation of the transcription factor ATF3 in mouse models of neurodegeneration. While ATF3 has been shown to have a protective role in motor neurons, little is known about its function within the brain. This studentship will use cell biological and biochemical approaches to investigate the effects of ATF3 expression in primary neurons at early stages of tauopathy. Understanding the mechanisms that underlie the neurodegeneration found in dementias is an important route to finding therapies for these diseases.
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