The University of Southampton

Unpacking the Nuremberg Code’s Legacy in Medical Research

Since 1947, a set of ten standards has existed to prevent harm to human subjects during clinical trials, following the infamous Nazi human experiments that took place during World War II in concentration camps. These horrific trials left many dead, and almost all survivors experienced permanent severe injuries. The crimes included transplantation, amputation, starvation, freezing and sterilization amongst others, and any victims who stood against the doctors were sent to the gas chambers. As much as it can be unanimously agreed that this is one of the greatest examples of brutal medical malpractice, it can be surprisingly difficult to unpack the ethics of using the collected knowledge in the 21st century for the advancement of modern health.

Jadwiga Dzido showing her scars from medical experiments

There are two major arguments against using the data obtained from the experiments. Over the years, the data has been used in multiple fields. I would like to focus on the Dachau freezing experiments, which are possibly the most controversial due to their prevalence in 20th-century research publications into the treatment of hypothermia. This involved ‘participants’ being submerged in tanks of ice water, some anesthetised, others conscious, to induce hypothermia, so that rewarming techniques could be tested on their efficacy and bodily responses. I use the term ‘participants’ extremely loosely, since this was done without consent, usually forced or under the false pretence of release from concentration camps.

Argument one considers the actual value of the data collected regardless of its ethics. Physician-scientist Andrew Ivy declared ‘Nazi experiments on humans were of no medical value’ at the Nuremberg war crime trials. However, recently, several investigators have suggested the Dachau study did produce credible data. Understandably, there is no ethical way to generate the data produced from this study, and important understandings on treating hypothermia could be life-saving. This is where argument two gains significance. The data gathered could potentially be considered ethically usable if it is for the greater good.

The experiment should be such as to yield fruitful results for the good of society, unprocurable by other methods or means of study, and not random and unnecessary in nature

– The Nuremberg Code

Conclusion

Now, the Dachau experiments completely go against all but one of the ten postulates of the Nuremberg Code. There was no informed voluntary consent, injury and suffering was certainly not avoided and there was absolutely no opportunity for the human subjects to terminate the trials. In every sense of the word, these experiments were not ethical. Whether they should have occurred is not up for debate. But since replication of these experiments is off the table, and lives could be saved with this knowledge, could it be suggested that the saving of lives is almost … honouring those who died and suffered? Equally, however, it could be argued that continuing to revoke their ability to consent is entirely dishonourable. In my opinion – in an ideal world, these experiments would never have happened. The 15,754 documented victims died needlessly. Despite this, if it can be agreed that the data collected is of scientific relevance and value, could be used for the greater good, and cannot be ethically replicated, this data should not go to waste, along with the legacy of the victims.

Computers for Brains – the Future of Humanity?

Implanting chips that can read our brain and control our movements sounds right for a science fiction film, but could technology like Neuralink help paralysed patients to walk and talk again?

Controversial businessman and CEO Elon Musk’s adventure into the world of bio-engineering seems to me like a frightful jump towards losing autonomy, and providing an additional way for large corporations to gain control of us – this time from inside our heads. However, if done correctly, these small chips could be the important missing piece in giving people suffering from paralysis the chance to live a normal life.

Earlier this year, Neuralink implanted its first device into a human. Via ‘X’, formerly known as twitter, Musk let the public know the patient was “recovering well”, and initial results seem “promising”. The clinical trial for Neuralink, PRIME – Precise Robotically Implanted Brain-Computer Interface – has been recruiting people with quadriplegia caused by a spinal cord injury or ALS (amyotrophic lateral sclerosis), in hopes of restoring movement.

“The device is designed to interpret a person’s neural activity, so they can operate a computer or smartphone by simply intending to move – no wires or physical movement are required”

– Neuralink

According to Neuralink, the implant consists of “1024 electrodes distributed across 64 threads”, and can be wirelessly charged through the skin. The implant would enable users to communicate directly with a mobile phone or computer, in goal of providing more indepedence to people living with disabilities.

Neuralink has not been without controversy, however, and animal cruelty accusations began in 2022 that up to 12 monkeys had been euthanised during the research and development process. Musk objected to these accusations, assuring “no monkey has died as a result of a Neuralink implant”, and that terminal animals were used in research to minimise risk.

Interfacing neurology with computers is not a new concept, for decades scientists have been decoding the electrical activity of the brain and looking for ways to manipulate this activity, mostly through the view of improving the lives of those with loss of function and senses of the body. On the other hand, implants have also been seen as a potential way to enhance the healthy and provide ‘superpowers’, for example by utilising Artificial Intelligence (AI) to increase the aptitude and intellect of healthy participants. This is where many argue we should draw the line, and an increased reliance on technology could lead to a diminished attention span, derealisation and a host of other negative consequences yet to be discovered yet. And what is to say that, with profits the leading force of almost all companies, advertisements will not begin playing inside our own head? Would there be any escape back to the natural world?