The University of Southampton

Just Out of Reach: Restoring Sensation with Prosthetic Technology

In the sensing and sensors lecture, we were shown an example of a prosthetic limb in 2021 with haptics responsive enough that a blindfolded 85-year-old could pick up a hollow eggshell without damaging it1.

This really made me think about the functions you’d need to replicate in a prosthetic arm beyond it being just an appendage for it to fulfill all the roles of the lost limb. I’d only come across haptics being used to extend a user’s ā€˜self’ in videogame hardware, but with some reflection and research (including on WW2 planes using haptics to forewarn pilots of stalls2) it made sense that the device increasingly becomes an extension of the user with improvements to effective information flow.

So what other sensations are there to improve this link? What other advancements have there been? The sense that immediately comes to mind is temperature, but following that, pain. Pain and discomfort naturally protect us from harm, driving you to avoid potential injury.

In 2018, researchers at Johns Hopkins’ University displayed an electronic synthetic skin called ā€œe-dermisā€. A structure of rubber and fabric with sensor ā€œnerve endingsā€ could interact with peripheral nerves of amputees, feeding back curvature and sharpness as ā€œtouchā€ and ā€œpainā€ respectively. The e-dermis can be implemented on existing prosthetics, enabling users to tell whether they were holding a sharp or smooth object3.

Later in 2020, RMIT University (Royal Melbourne Institute of Technology) developed another electronic synthetic silicone skin. Vanadium oxide’s electronic behaviour changes in response to temperatures above 65˚C, creating a temperature trigger when integrated into the ā€œskinā€ for pain decision making. Researchers suggested potential applications in non-invasive skin-grafts upon further development, with the ā€œbrain-mimicking circuitā€ having adjustable thresholds to modify sensitivity4.

The temperature sensitive synthetic skin from RMIT

For anyone reading on these advancements there’s a point that probably stands out though. Do the advantages of simulated pain outweigh the discomfort a prosthetic could inflict on the user when the sensor is on a repairable part?

ā€œAfter many years, I felt my hand, as if a hollow shell got filled with life again,ā€-Anonymous principal volunteer tester3.

When implementing the ā€œe-dermisā€, stimuli produced by the synthetic skin matched sensations in users’ phantom limbs. Additionally, interaction with peripheral nerves is increasingly well documented to reduce phantom limb pain5,6,7. If reactive pain and sensory feedback can reduce persistent phantom limb pain in amputees, improving brain body mapping for prostheses, the very pain and discomfort we want to avoid could act to unify prosthetic and person.

I was also curious what advancements in sensory prosthetics could do for those paralysed by extension. A 2025 study by researchers at the University of Chicago8 worked with individuals with spinal cord injuries. Electrodes were implanted into the sensory and motor regions of the brain, allowing not only control of a robotic arm and hand, but sensation through it. Subjects could feel edges, shapes and movement through their connection to the robotic arm.

Amazingly, subjects had such good control of the limb they could even drive cars (in simulation).

Pictured use of the robotic hand, taken from the University of Chicago Medicine site.

The development of sensation in prosthetics is so much further than I realised, where else could these technologies go? Where else might they end up? Ā If pain, touch, and temperature feedback can be integrated into artificial limbs, could future developments allow individuals to experience a completely artificial yet fully sensory body?

References

Ctrl+P: Bio-printing, how it works and societal concerns.

Donor organ transplants

The human body has a limited capacity to heal or regenerate compromised organs. Currently these are normally replaced via transplant from a compatible donor, but there can be complications with rejection when the immune system recognises the transplanted tissue as foreign and there is the initial issue of having enough donors within society to provide the organs needed for transplants everyday. Those of us in the UK should be especially aware of donor shortages, given we must opt out of the organ donor register per the Organ Donation Bill (2019) as consent for donation is automatically assumed otherwise.

A possible solution

Bio-printing uses common 3D printing techniques to construct organs or other bio-materials from base cells in a ‘bio-ink’. Potentially, those waiting for organs could have one purpose printed or their damaged organ repaired (with successful stem cell use demonstrated for both), cutting the risk of rejection and wait time.

Printers?, Ink?, Like a regular printer? Bio-inks are predominantly blends of alginate-gelatine that contain desired cells. The properties of this material must be specialised for its use and the method of printing involved, optimal cell growth and tissue integrity has to be maintained for the cell payload, print temperature and pressure can kill the cells during delivery if not set correctly. Simultaneously the gelatin must be viscous enough for delivery and yet achieve a balance of flexibility and sturdiness once in place to replicate organs as if grown in situ.

The printers involved vary, but most may be familiar, inkjet printers similar to the one on your desk (and possibly built by the same company e.g. Hewlett-Packard) heat the ink and eject it onto the build plate via an array of nozzles in the printhead. Stereolithography (already used by hobbyists like myself with non-bio photopolymers), targets UV or visible light onto a build plate, upon which the bio-ink undergoes a chain reaction from liquid gelatine to a solid scaffold for growth under light exposure.

Extrusion printers build a structure with supports layer by layer, the material is either pushed out of a syringe in liquid form under pressure via pneumatics, pistons or screws or fed into a controlled heated nozzle (called a hot end), liquified and deposited directly onto the structure, the latter being the same premise as for FDM (Fused Deposition Modelling) printers.

HP Inkjet bio-printer
Visuals for how the processes work.

Bio-printing in fiction and societal views

Those of you who’ve read books such as Kiln People or Queen of Angels or watched Westworld know the concerns that can arise with bio-printing. Body modification, cloning and exploitation of humans made through bio-printing have been explored in our media, so what standards can we hold bio-printing to? I myself own two (non-bio)printers, they’re incredibly easy processes to pick up and find equipment for (there have been open source instructions to build your own bio-printer for under Ā£400 from Carnegie Mellon University since 2018) and yet there is no sui generis regulatory body governing the entire process, only partial coverage for the biological material itself under the HTA for tissues and HFEA for stem cells.

My closing thoughts

The concerns above are significant, and yet it seems to me the industry might be getting ahead of being assessed and regulated. Although we’re nowhere near printing the hosts, if someone can inexpensively decide to make their own bio-printers, why don’t specific regulation bodies exist and how could they monitor such possibilities when the process can feasibly be completed in the comfort of your own home.

Westworld (tv series) opening- the park’s hosts are automatons with organic bodies.

References

Information on opt-in, opt-out system: https://www.organdonation.nhs.uk/helping-you-to-decide/about-organ-donation/faq/what-is-the-opt-out-system

Ong, C. S., Yesantharao, P., Huang, C. Y., Mattson, G., Boktor, J., Fukunishi, T., Zhang, H., & Hibino, N. (2018). 3D bioprinting using stem cells.Ā Pediatric research,Ā 83(1-2), 223–231. https://doi.org/10.1038/pr.2017.252

Murphy, S., Atala, A. (2014). 3D bioprinting of tissues and organs.Ā Nat BiotechnolĀ 32, 773–785. https://doi.org/10.1038/nbt.2958

Chung J, Kapsa R. (2013) Bio-ink properties and printability for extrusion printing living cells. Biomaterials Science. http://dx.doi.org/10.1039/C3BM00012E

Kirillova A, Bushev S, Abubakirov A, Sukikh G. (2020) Bioethical and Legal Issues in 3D Bioprinting. Int J Bioprint; 6(3):272. doi: 10.18063/ijb.v6i3.272.

S. Vanaei, M.S. Parizi, S. Vanaei, F. Salemizadehparizi, H.R. Vanaei, (2021) An Overview on Materials and Techniques in 3D Bioprinting Toward Biomedical Application, Engineered Regeneration, Volume 2, https://doi.org/10.1016/j.engreg.2020.12.001.

Herzog, Josha & Franke, Lea & Lai, Yingyao & Rossi, Pablo & Sachtleben, Janina & Weuster-Botz, Dirk. (2024). 3D bioprinting of microorganisms: principles and applications. Bioprocess and Biosystems Engineering. 47. 1-19. doi: 10.1007/s00449-023-02965-3.

Open source instructions for a bioprinter from CMU: https://engineering.cmu.edu/news-events/news/2018/03/23-bioprinter-feinberg.html