The University of Southampton

Lab Grown Meat?

I recently saw an article about lab-grown meat and how it soon may be coming to UK supermarkets. In fact, cultured meat has been used in dog food since February this year, and in 2020 Singapore allowed cell-cultured meat for human consumption1. However, its use in our food is still awaiting approval by the FSA.

How is meat grown in a lab?

Lab-grown meat, also known as cultured or cultivated meat, is meat developed from a culture of animal cells instead of being farmed from slaughtered animals.

There are four main steps involved in its production2:

  1. A stem cell sample is taken from a living animal (e.g. embryonic stem cells or skeletal muscle stem cells: myosatellite cells3)
  2. These stem cells are put in large bioreactors which contain culture media that creates a favourable environment, one similar to the host animal’s body. These culture media also provides nutrients that the stem cells need for growth.
  3. The culture media is then changed to a provide a different environment, one that allows the stem cells to differentiate into muscle, fat and connective tissue.
  4. These different types of cells are separated and used in scaffolding: where the meat is “built” on an edible scaffold (made of collagen and gelatin4) that provides support for the meat cells. This allows them to arrange themselves in the correct way to create the desired meat shape, e.g. minced meat or a steak. The scaffold also provides more nutrients for the cells to further differentiate and make the correct tissues.

Why use cultured meat?

Firstly, growing meat in a laboratory means that animals won’t need to be raised and slaughtered for their meat. This presents benefits like less space and resources being used, as large amounts of animals won’t need to be farmed. A more sustainable method of meat production is beneficial to the environment, especially due to current concerns about climate change caused by, for example, deforestation to make space for herding. Decreasing the amount of animals slaughtered also means that animal rights and welfare will improve, and people who don’t eat meat due to animal cruelty might choose to reintroduce meat into their meals (which is important for a healthy, balanced diet).

Since this meat is grown in controlled laboratory conditions, the risk of parasites, diseases and other pathogens is lowered as the environment the meat is grown is heavily regulated. Common issues such as parasites or bacteria (E. coli, salmonella) could be avoided using cultured meat.

Drawbacks

Studies show that although cultured meat will reduce methane emissions due to cattle farming, its production could contribute to CO2 emissions over a long period. Cultivated meat also requires a large amount of energy, potentially contributing to greenhouse gases if renewable sources aren’t used5.

Personally, I think lab-grown meat does have a role in the future of food as it could also be modified to contain less saturated fats and be overall healthier. However, a large number of people will try to avoid it due to doubting its safety or having a preference that “real” meat tastes better.


References

  1. Rowlatt, J. (2025). Lab-grown meat goes on sale in UK dog food. BBC News. [online] 9 Feb. Available at: https://www.bbc.co.uk/news/articles/cwy12ejz0mwo.
  2. Eufic (2023). Lab grown meat: how it is made and what are the pros and cons. [online] www.eufic.org. Available at: https://www.eufic.org/en/food-production/article/lab-grown-meat-how-it-is-made-and-what-are-the-pros-and-cons.
  3. ‌Swartz, E. and Bomkamp, C. (2022). The Science of Cultivated Meat. [online] The Good Food Institute. Available at: https://gfi.org/science/the-science-of-cultivated-meat/.
  4. ‌Seah, J.S.H., Singh, S., Tan, L.P. and Choudhury, D. (2021). Scaffolds for the manufacture of cultured meat. Critical Reviews in Biotechnology, 42(2), pp.1–13. doi:https://doi.org/10.1080/07388551.2021.1931803.
  5. ‌Lynch, J. and Pierrehumbert, R. (2019). Climate Impacts of Cultured Meat and Beef Cattle. Frontiers in Sustainable Food Systems, 3(5). doi:https://doi.org/10.3389/fsufs.2019.00005.

The Hernia Mesh “Controversy”

Every year, the NHS performs almost 100,000 hernia related surgeries, with 75% of surgeries using a mesh. However during one of our prosthesis lectures, I was surprised to hear about hernia meshes being controversial. So why would such a popular procedure have a negative reputation?

What is a hernia?

Hernias occur when a hole or a weak spot in tissue allows organs or fatty tissue to poke through, the most common hernia in the UK being an inguinal hernia in the groin, but they can also occur in the abdomen. A polypropylene or polyester mesh can be inserted to provide permanent support to the weakened area, which are thin and flexible and don’t react with the body. Absorbable meshes can also be used, where they provide short-term support while new tissue regrows and repairs the area.

What’s wrong with permanent meshes?

Although most of hernia surgeries go well, many people still experience complications. The most common problems with hernia surgeries are pain, adhesion of scar-like tissue, hernia recurrence, infection, bleeding, abnormal connections between organs and obstruction of the large or small intestine. Permanent hernia mesh surgeries have an additional risk of the mesh migrating to a different place, shrinkage of the mesh itself and risk of the mesh reacting with the body and being rejected. There have also been concerns that meshes can cut into tissue and nerves, causing difficulties with walking and every day life.

International guidelines estimate 1 in 10 people who had a mesh repair surgery will experience significant chronic pain. This means every year, roughly 10,000 people in the UK will suffer from chronic pain due to a surgery that should’ve improved their quality of life.

Benefits of hernia meshes.

Hernia recurrences are a major concern, especially with non-mesh surgeries. The use of a mesh, whether it’s permanent or absorbable, significantly reduces the chances of a hernia recurrence. The reduced likeliness of the hernia developing again is one of the main reasons a mesh is preferred, as each subsequent surgery for a hernia has higher chances of complications, such as more scar tissue forming. Using a hernia mesh also allows reduced surgery time and quicker recovery time compared to non-mesh surgeries.

Alternatives

An alternative to classic hernia meshes can be “hybrid” meshes, such as Ovitex made by TELA Bio. This mesh is made of different materials: the main structure is made of polypropylene, and sheep stomach is used to make an absorbable component that’s mainly collagen. Once the collagen is absorbed by the body, there is still a small part of the mesh that’s left behind to provide structural support, but reduces the amount of synthetic mesh present in the body. This has already been used in the ReBAR Technique (Reinforced Biologic Augmented Repair).


References

Lucian Panait (2021). Inguinal Hernia: To Mesh or Not to Mesh? – Minnesota Hernia Center. [online] Minnesota Hernia Center. Available at: https://mnhernia.com/inguinal-hernia-to-mesh-or-not-to-mesh/ [Accessed 11 Mar. 2025].

Pawlak, M., Tulloh, B. and de Beaux, A. (2020). Current trends in hernia surgery in NHS England. The Annals of The Royal College of Surgeons of England, 102(1), pp.25–27. doi: https://doi.org/10.1308/rcsann.2019.0118

Health, C. for D. and R. (2023). Surgical Mesh Used for Hernia Repair. [online] FDA. Available at: https://www.fda.gov/medical-devices/implants-and-prosthetics/surgical-mesh-used-hernia-repair.

Collinson, A. (2020). Hernia mesh implants used ‘with no clinical evidence’. BBC News. [online] 15 Jan. Available at: https://www.bbc.co.uk/news/health-51024974.