The University of Southampton

Sensing: can it revolutionise diagnostics for ADHD?

What is ADHD? 

ADHD (Attention Deficit Hyperactivity Disorder) is a neurodevelopmental condition linked to inattention, overactivity and impulsivity1.

After attending the workshop on sensing, I learned about how tools such as EEG can detect and monitor activity within the brain. I was intrigued about the uses of EEG sensing, especially its applications for the research of neurodevelopmental disorders. EEG senses alpha and beta waves which are linked to changes in focus within the brain. This made me curious about how something that seems so clearly identifiable is not currently being used to aid or complete an ADHD diagnosis. The diagnostic process is currently analytical of expressed symptoms rather than directly analysing the brain.

I was diagnosed with ADHD at age 18 and struggled with the length and self-analysis required for the process. The prospect of using sensing to analyse the brain with a more simple ‘clear cut’ answer based on science with a reduced time frame seems very intriguing.  It has the potential to be more ethical by alleviating some of the stress of the process, benefitting society.

Scientific imaging of ADHD brains

After observing the brains in the organ tanks during the anatomy lab, I was curious about differences in brain structures of people with ADHD.  One study used MRI scanning to compare 20 brains of people with ADHD and compared the structures to brains of people without ADHD. It was found that there were differences in brain volume of grey and white matter. A trend in reduced size of the amygdala was also found, which can be linked to trouble with emotional regulation, a major symptom of the disorder2. Safety concerns of MRI may make this form of diagnostics less ethical.

Alpha and beta waves – what do they mean?

EEG traces can identify alpha and beta waves. Alpha waves (8-13-2Hz) indicate relaxed awareness without attention while beta waves (12-30Hz) indicate active thinking and attention. EEG is safe and non-invasive which helps to reduce ethical concerns about safety of diagnosis3.

Conclusion

The discussion of applying pattern recognition to prosthetics, making me curious about applications of this process to ADHD. However, the nature of the disorder may complicate the process. This viewpoint is strengthened by a study stating variation found in their own neuroimaging could be due complexities in the disorder. Their finding meant that despite advancements in equipment, the disorder cannot always be directly interpreted due to its’ presentation, making it difficult to form a diagnosis2.

Despite this, the study then stated that researchers intend to use neuroimaging techniques that identify biomarkers as an ‘objective diagnostic tool for ADHD’2. A news article also seemed optimistic about the diagnostic opportunities new sensing technologies bring, click here to read.

Some people may be concerned about effects on their employment or dislike the sensing process as it may feel upsetting to detect differences in the brain. However, the disability discrimination act 1992 ensures that diagnosed patients cannot be discriminated against.  Personally, I would find it easier to understand how ADHD makes me different. Sensing may help society to more accurately diagnose patients, improving healthcare and reducing legal action linked to misdiagnosis.

To conclude, I believe there are opportunities to improve diagnostics with sensing with more research and time.

References:

  1. Tripp G, Wickens JR. Neurobiology of ADHD. Neuropharmacology. 2009 Dec 1;57(7-8):579-89.
  2. Lim S, Yeo M, Yoon G. Comparison between concentration and immersion based on EEG analysis. Sensors. 2019 Apr 8;19(7):1669.
  3. Albajara Sáenz A, Villemonteix T, Massat I. Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder. Developmental Medicine & Child Neurology. 2019 Apr;61(4):399-405

Should women be paid for egg donation? 

A brief introduction

One topic mentioned in the ethics workshop was egg donation. This is the practice of women donating their eggs either for IVF treatments or for scientific research. There is great variation in the payment of women in different cultures, sparking debate over how donors should be compensated.

How does the process work?

The process of egg collection is lengthy, taking two to three months. Genetic screening is also required before the egg collection occurs which follows a few key steps. 

Firstly, hormone treatment occurs on day two of the cycle. This is done via daily FSH injections to boost the number of follicles formed. Secondly, after a few days of FSH injections antagonist injections occur to supress natural hormone production of the cycle. At this stage blood tests and scans are needed to check for responses to the medication. Further antagonist injections then help the eggs mature. Finally, to collect the eggs from the body pain relief via sedation or general anaesthetic may also be required. The collected eggs are then used fresh or are frozen for later use.

The UK law of egg donation

In the UK it is illegal to profit from this practice however compensation of £985 per cycle (one complete round of treatment) is allowed.  This compensation is strictly processed based, not for actual donation and more can also be claimed to cover fees for expenses such as travel, accommodation and childcare.

Egg donation in the US

In the US the ASRM (American Society for Reproductive Medicine) requirements must be met, and it is possible to donate anonymously which is different to the UK law.

The cost of fresh egg donation ranges from $35, 000 to $50, 000 and is not always limited to processed based compensation, differing to UK law.

Ethical arguments in favour of payment

Egg donation is time consuming due to the duration travel and process. Daily injections also make it extremely inconvenient. There is also a risk to the health of the donor including risks associated with medication such as general anaesthetic and there is potential risk to life due to OHSS and side effects.

Counselling is also legally required, demonstrating the large mental health impact which can be long lasting and not fairly compensated for as mental health affects every aspect of life.

These reasons describe how it could be argued that there is not enough compensation for the risk taken by the donors.

Additionally, the US system assigns great value to the donated eggs which is reflected by the price women are paid for their eggs.

Ethical problems with payment for Egg donation

Major problems associated with paying for egg donation include encouragement to undergo a complicated and painful procedure for those that more urgently need money. A monetary incentive and other potential pressures could also introduce ethical issues about true consent which can be eliminated if the process is voluntary and unpaid.

Overall conclusions

It is a difficult topic with no complete solution. The current UK system allowing some compensation to cover the actual cost of donation feels the most appropriate to me as it offers a middle ground where the women are somewhat looked after but no moral compromises are made. However, a slight increase in the maximum compensation limit could better support the women.

Sources:

  1. Donating your eggs | HFEA
  2. Egg Donor Laws by States – A Comprehensive Guide
  3. Egg donor compensation is to triple under new HFEA guidelines – BBC News
  4. How Much Can You Get Paid for Donating Eggs? – GoodRx