The University of Southampton

Ethical Concerns of Embryonic Stem Cells

The Future and Ethics of Stem Cell Research

It is clear that the future of medicine lies in stem cell research, offering treatment possibilities for an enormously wide range of diseases using the body’s own healing mechanisms. However, stem cell research faces many ethical implications, posing a dilemma between morality and furthering scientific innovation.

What are Stem Cells

Stem cells are undifferentiated cells that have the potential to become many types of specialised cells. The ethical problems lie in collecting the totipotent embryonic stem cells, as it is seen that a potential or current life (depending on your viewpoint) has been ended for the scientific community.

Stem cells have been linked to the cure for Parkinson’s, Alzheimer’s and type 1 diabetes plus all tissue damage-related injuries can be eliminated. They are also useful in the creation of ā€˜knockout mice’ that can assess the function of a gene.

Ethical Concerns

Ethical concerns are raised with the use of embryonic stem cells as the creator of the first embryonic stem cells, James Thompson says ā€œIf human embryonic stem cell research does not make you at least a little bit uncomfortable, you have not thought about it enoughā€.

Various arguments are suggested as to what makes a human life significant such as potential of life, viability, consciousness and sentience. This introduces controversy into the argument, as there is no correct answer to these questions. Is there a defined age when consciousness emerges? For instance, the earliest memory of my friend is folding origami in a dress aged 4, so can we be sure he had consciousness before then if he has no memory of it? However, if it was suggested that it is ok to kill a 3-year-old, the person who suggested it would be jailed, so is consciousness a spectrum?

Many say that it is ethically right to use spare embryos that are spare after fertilisation procedures, however, this leads to issues raised with the case of Julius Hallervorden. Hallervorden was a Nazi scientist that made discoveries that furthered our understanding of cerebral palsy and many types of brain cancer, however, he used the brains of already dead eugenics victims (that would have gone to waste else wise). Was he wrong to take this opportunity to research the brain? Or was he morally obligated to not let those samples go to waste to save more lives in the future?

These questions can be answered in the various schools of thought that are found in ethics. Aristotle’s ethics as virtue claims that morality is based on purpose i.e. a good soldier is one that performs their duties well. This would make Hallervorden a ā€˜good scientist’ and make his actions morally right. On the other hand, Kantian deontology is more critical of his actions as he ignored his duty as a physician to preserve human life and instead used them as tools for research.

Conclusion

The ethical question of the use of stem cells is a deep well of ethical mess with no correct answer. As we move into the future, research will be directed towards induced pluripotent cells, however, the questions over embryonic stem cells won’t go away as they will pose a huge role in comparing against the induced pluripotent cells to test their efficacy. It should also be noted that that technology is not developed yet, so we have no promise that these cells will be as effective as the embryonic versions. To conclude, embryonic stem cells are an incredible tool, but as is the nature of great tools, the more good it brings, the more evil it can bring.

The Future and Ethics of Stem Cell Research

It is clear that the future of medicine lies in stem cell research, offering treatment possibilities to an enormously wide range of diseases using the body’s own healing mechanisms. Despite this, stem cell research faces many ethical implications (particularly embryonic stem cells), posing a dilemma between morality and furthering scientific innovation.

What are Stem Cells

Stem cells are undifferentiated cells that have the potential to become many types of specialised cells. The ethical problems lie in collecting the stem cells a there are two separate types: adult (somatic) and embryonic. Adult stem cells are multipotent, meaning they can differentiate into a wide range of specialised cells, but they are limited and they eventually sensece. In comparison, embryonic stem cells are pluripotent, meaning they can divide into any cell type.

Why are Stem Cells Useful?

The potential of stem cells is massive, it is believed that they could be involved in the cure for Parkinsons’s, Alzheimer’s and type 1 diabetes. Conditions relating to tissue damage could become things of the past as scarred tissue from liver cirrhosis or scarred heart tissue from heart disease can be replaced without the need for an organ transplant. They are also useful in laboratory purposes as they are useful in making ‘knockout mice’. Knockout mice are made from mating two chimeric mice in which you can remove certain genes, giving a great insight into what each gene does.

Ethical Concerns

Adult stem cells pose little ethical dilemma as all the methods used to extract them pose very little risk, the most common being a bone marrow extraction under local anaesthetic. Ethical dilemmas are raised when embryonic stem cells are used because it can be seen as destroying an early human life, raising the ethical question: when does a human life start?

While those who argue against the use of embryonic stem cells argue that the embryo has a potential for life and therefore the elimination of it is equivalent to the taking of a human life. The argument against this is that there are countless spare embryos after fertilisation procedures that would be discarded anyway, so scientific testing that could save and improve lives is not just permitted, but the right thing to do.

To combat these ethical concerns, a surprising discovery was made that by knocking out 4 genes, adult skin cells could be reverted into pluripotent cells. This helps deal with the ethical dilemma of harvesting the stem cells, but it raises more questions relating to the idea of human enhancement.

Conclusion

This ethical dilemma is a cornerstone moment for human scientific research because it creates a line between morality and scientific research. How far are we willing to go to understand how our body works? Is it okay to cross moral lines against embryos in order to save more lives in the future? At what point do biological enhancements make a person inhuman? The answers to all of these questions will be used as the precedent for the future of medicine.