{"id":5887,"date":"2023-07-24T13:45:05","date_gmt":"2023-07-24T12:45:05","guid":{"rendered":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/?page_id=5887"},"modified":"2024-02-23T13:21:06","modified_gmt":"2024-02-23T13:21:06","slug":"research","status":"publish","type":"page","link":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-cover alignfull has-dm-sans-font-family\" style=\"margin-top:0;text-transform:lowercase;min-height:315px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-70 has-background-dim wp-block-cover__gradient-background has-background-gradient\" style=\"background:linear-gradient(135deg,rgb(44,44,97) 15%,rgb(0,189,212) 50%,rgb(0,136,171) 84%)\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"1029\" height=\"1110\" class=\"wp-block-cover__image-background wp-image-4783\" alt=\"\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo.jpg\" style=\"object-position:52% 6%\" data-object-fit=\"cover\" data-object-position=\"52% 6%\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo.jpg 1029w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo-278x300.jpg 278w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo-949x1024.jpg 949w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo-768x828.jpg 768w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2018\/10\/oreffo-osteo-46x50.jpg 46w\" sizes=\"auto, (max-width: 1029px) 100vw, 1029px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div style=\"height:0px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"has-text-align-center has-base-color has-text-color has-dm-sans-font-family has-x-large-font-size\" style=\"font-style:normal;font-weight:700;line-height:1;text-transform:none\">We use lifecourse epidemiological methods to reduce<\/p>\n\n\n\n<p class=\"has-text-align-center has-base-color has-text-color has-dm-sans-font-family has-x-large-font-size\" style=\"font-style:normal;font-weight:700;line-height:1;text-transform:none\">the population burden of chronic musculoskeletal <\/p>\n\n\n\n<p class=\"has-text-align-center has-base-color has-text-color has-dm-sans-font-family has-x-large-font-size\" style=\"font-style:normal;font-weight:700;line-height:1;text-transform:none\">disease and disability.<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Our Programmes:<\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-light-grey-backdrop-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-3a02abfb wp-block-group-is-layout-constrained\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<div class=\"wp-block-group alignwide has-base-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-201a1795 wp-block-group-is-layout-constrained\" style=\"border-width:2px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-group alignwide has-base-color has-tertiary-background-color has-text-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<h4 class=\"wp-block-heading alignwide has-text-align-left\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\"> <strong>Programme 1 &#8211; Musculoskeletal health in later life<\/strong><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\"><figure class=\"wp-block-media-text__media\" style=\"background-image:url(http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2019\/04\/p3-hrh-cornwall.jpg);background-position:60% 31%\"><a href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/musculoskeletal-health-in-later-life\/\"><img loading=\"lazy\" decoding=\"async\" width=\"727\" height=\"484\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2019\/04\/p3-hrh-cornwall.jpg\" alt=\"\" class=\"wp-image-4984 size-full\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2019\/04\/p3-hrh-cornwall.jpg 727w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2019\/04\/p3-hrh-cornwall-300x200.jpg 300w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2019\/04\/p3-hrh-cornwall-50x33.jpg 50w\" sizes=\"auto, (max-width: 727px) 100vw, 727px\" \/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<li>The changing descriptive epidemiology of musculoskeletal diseases; osteoporosis (low trauma fractures), sarcopenia (low muscle mass and strength) and osteoarthritis (joint disease) in adult populations.   <\/li>\n\n\n\n<li>The underlying determinants of bone and muscle health across later adulthood.Identify and test novel strategies to optimize muscle and bone health in older age<\/li>\n\n\n\n<li>Identify and test novel strategies to optimize muscle and bone health in older age<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/musculoskeletal-health-in-later-life\/\">Read more<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-light-grey-plus-backdrop-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-3a02abfb wp-block-group-is-layout-constrained\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<div class=\"wp-block-group alignwide has-base-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-201a1795 wp-block-group-is-layout-constrained\" style=\"border-width:2px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-group alignwide has-base-color has-tertiary-background-color has-text-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<h4 class=\"wp-block-heading alignwide has-text-align-left\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\"><strong>Programme 2: Determinants of musculoskeletal health in the mid-lifecourse<\/strong><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\"><figure class=\"wp-block-media-text__media\" style=\"background-image:url(http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2015\/08\/prog5-climbing.png);background-position:51% 14%\"><a href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/musculoskeletal-health-in-later-life\/\"><img loading=\"lazy\" decoding=\"async\" width=\"319\" height=\"426\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2015\/08\/prog5-climbing.png\" alt=\"\" class=\"wp-image-3293 size-full\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2015\/08\/prog5-climbing.png 319w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2015\/08\/prog5-climbing-225x300.png 225w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2015\/08\/prog5-climbing-37x50.png 37w\" sizes=\"auto, (max-width: 319px) 100vw, 319px\" \/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<li>reduce the disability for work caused by musculoskeletal disorders<\/li>\n\n\n\n<li>further explore the impacts of working to older ages on health and future healthy retirement<\/li>\n\n\n\n<li>prevent musculoskeletal disorders caused by work<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/determinants-of-musculoskeletal-health-in-the-mid-lifecourse\/\">Read more<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-light-grey-backdrop-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-3a02abfb wp-block-group-is-layout-constrained\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<div class=\"wp-block-group alignwide has-base-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-201a1795 wp-block-group-is-layout-constrained\" style=\"border-width:2px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-group alignwide has-base-color has-tertiary-background-color has-text-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<h4 class=\"wp-block-heading alignwide has-text-align-left\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\"><strong>Programme 3: Early development and risk of adult musculoskeletal disease<\/strong><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\"><figure class=\"wp-block-media-text__media\" style=\"background-image:url(http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2022\/02\/dxa-scan.png);background-position:25% 32%\"><a href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/musculoskeletal-health-in-later-life\/\"><img loading=\"lazy\" decoding=\"async\" width=\"284\" height=\"178\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2022\/02\/dxa-scan.png\" alt=\"\" class=\"wp-image-5609 size-full\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2022\/02\/dxa-scan.png 284w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2022\/02\/dxa-scan-50x31.png 50w\" sizes=\"auto, (max-width: 284px) 100vw, 284px\" \/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<li>To elucidate the risk factors for, and mechanisms which underlie, the developmental origins of osteoporosis and other musculoskeletal disorders; and to develop intervention studies aimed at modifying later disease risk through nutritional and other interventions targeted at critical periods of early development.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\">Read more<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-light-grey-plus-backdrop-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-3a02abfb wp-block-group-is-layout-constrained\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<div class=\"wp-block-group alignwide has-base-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-201a1795 wp-block-group-is-layout-constrained\" style=\"border-width:2px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-group alignwide has-base-color has-tertiary-background-color has-text-color has-background is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<h4 class=\"wp-block-heading alignwide has-text-align-left\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\"><strong>Programme 4: Early nutrition intervention studies<\/strong><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\"><figure class=\"wp-block-media-text__media\" style=\"background-image:url(http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2021\/11\/vitamin-d.jpg);background-position:50% 38%\"><a href=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/research\/musculoskeletal-health-in-later-life\/\"><img loading=\"lazy\" decoding=\"async\" width=\"339\" height=\"226\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2021\/11\/vitamin-d.jpg\" alt=\"\" class=\"wp-image-5522 size-full\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2021\/11\/vitamin-d.jpg 339w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2021\/11\/vitamin-d-300x200.jpg 300w, https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-content\/uploads\/sites\/475\/2021\/11\/vitamin-d-50x33.jpg 50w\" sizes=\"auto, (max-width: 339px) 100vw, 339px\" \/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<li>The overarching objectives are to optimise diet behaviours and nutrition before conception and during pregnancy to improve the capacity and health of the next-generation, and to understand the mechanisms linking pre-conception and fetal nutrition to lifelong health.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\">Read more<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-contrast-color has-pale-cyan-blue-background-color has-text-color has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\" style=\"border-width:2px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<h4 class=\"wp-block-heading alignwide\">Data Sharing<\/h4>\n\n\n\n<p>We are keen to maximise the use of data from our cohorts, trials and other studies, and welcome approaches from researchers to explore use of the data. We have a procedure for data sharing to ensure that we preserve the confidentiality of the data and we need to abide by the terms of participant consent for each study. Our model for data sharing is a collaborative one and we work with researchers using the data to support them in the interpretation of the various data variables and of their findings. <\/p>\n\n\n\n<p>If you are interested in using our data, please email the Centre on <a rel=\"noreferrer noopener\" href=\"mailto:mrclec@mrc.soton.ac.uk\" target=\"_blank\">mrclec@mrc.soton.ac.uk<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Our Programmes: Programme 1 &#8211; Musculoskeletal health in later life Programme 2: Determinants of musculoskeletal health in the mid-lifecourse Programme 3: Early development and risk of adult musculoskeletal disease Programme 4: Early nutrition intervention studies Data Sharing We are keen to maximise the use of data from our cohorts, trials and other studies, and welcome [&hellip;]<\/p>\n","protected":false},"author":5281,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5887","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/pages\/5887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/users\/5281"}],"replies":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/comments?post=5887"}],"version-history":[{"count":66,"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/pages\/5887\/revisions"}],"predecessor-version":[{"id":6794,"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/pages\/5887\/revisions\/6794"}],"wp:attachment":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/mrclec\/wp-json\/wp\/v2\/media?parent=5887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}