{"id":2665,"date":"2015-07-06T14:27:42","date_gmt":"2015-07-06T13:27:42","guid":{"rendered":"http:\/\/www.dial-a-molecule.org\/wp\/?p=2665"},"modified":"2015-11-05T15:54:44","modified_gmt":"2015-11-05T15:54:44","slug":"registrations-open-lead-oriented-synthesis-exploring-drug-relevant-chemical-diversity","status":"publish","type":"post","link":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/registrations-open-lead-oriented-synthesis-exploring-drug-relevant-chemical-diversity\/","title":{"rendered":"Lead-Oriented Synthesis: Exploring Drug-Relevant Chemical Diversity"},"content":{"rendered":"

 <\/p>\n

“Lead-Oriented Synthesis: Exploring Drug-Relevant Chemical Diversity<\/strong>“<\/span><\/div>\n

\nFriday 25 September<\/span><\/strong><\/strong><\/div>\n
GSK Stevenage<\/span><\/strong><\/strong><\/div>\n

The ready availability of structurally novel lead molecules with appropriately controlled molecular properties (e.g. logP, molecular weight and fraction of sp3<\/sup> atoms) is crucial to the ability of the pharmaceutical industry to bring new small molecule drugs to market. However, it is now recognised that access to such lead molecules is poorly served not only by many current commercial libraries but also by the synthetic methods widely adopted within industry and many of those developed in academic laboratories. In this meeting, approaches to rectifying this issue will be presented both from academia and industry, with the hope of stimulating a broader recognition of, and solutions to, the challenges of lead-oriented synthesis.<\/p>\n

Meeting report:<\/strong><\/span> open in a new window<\/a><\/p>\n

Program:<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
09:45<\/strong><\/td>\nRegistration and coffee<\/strong><\/td>\n<\/tr>\n
10:30<\/strong><\/td>\nWelcome and housekeeping<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf. Adam Nelson (University of Leeds)<\/em><\/td>\n<\/tr>\n
10:40<\/strong><\/td>\nHow synthetic chemistry can drive the discovery of drugs of the future<\/strong><\/td>\n<\/tr>\n
<\/td>\nDr Ian Churcher (GSK)<\/em><\/td>\n<\/tr>\n
11:00<\/strong><\/td>\nExploring 3D pharmaceutical space: lead-oriented and fragment-oriented synthesis\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf. Peter O’Brien (University of York)<\/em><\/td>\n<\/tr>\n
11:40<\/strong><\/td>\nLLAMA: An open-access tool to guide lead-oriented synthesis<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf. Adam Nelson (University of Leeds) & Dr Richard Doveston (TU Eindhoven)<\/em><\/td>\n<\/tr>\n
12:00<\/strong><\/td>\nLunch and freeware demonstration<\/strong><\/td>\n<\/tr>\n
13:15<\/strong><\/td>\nSynthetic strategies for the efficient exploration of lead-like space<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf. Steve Marsden (University of Leeds)<\/em><\/td>\n<\/tr>\n
13:55<\/strong><\/td>\nDesign and exploitation of novel medicinal chemistry reagent sets<\/strong><\/td>\n<\/tr>\n
<\/td>\nDr Jason Kettle (AstraZeneca)<\/em><\/td>\n<\/tr>\n
14:35<\/strong><\/td>\nEnriching chemical space to drug undruggable targets<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf. David Spring (University of Cambridge)<\/em><\/td>\n<\/tr>\n
15:15<\/strong><\/td>\nAfternoon refreshments<\/strong><\/td>\n<\/tr>\n
15:45<\/strong><\/td>\nCross coupling 2.0<\/strong><\/td>\n<\/tr>\n
<\/td>\nProf Jeffrey Bode (ETH Zurich)<\/em><\/td>\n<\/tr>\n
16:45<\/strong><\/td>\nConcluding remarks and close of meeting<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Organising Committee:<\/strong><\/span> Prof Steve Marsden & Prof Adam Nelson<\/p>\n","protected":false},"excerpt":{"rendered":"

Join us on September 25th for a meeting designed to stimulate a broader recognition of, and solutions to, the challenges of lead-oriented synthesis. \u00a0More information, including confirmed speakers, can be found here.<\/p>

Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[5,7],"tags":[34,40,48],"class_list":["post-2665","post","type-post","status-publish","format-standard","hentry","category-events","category-news-2","tag-drug-discovery","tag-events","tag-meetings","nodate","item-wrap"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p6CjJ1-GZ","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/comments?post=2665"}],"version-history":[{"count":5,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2665\/revisions"}],"predecessor-version":[{"id":3301,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2665\/revisions\/3301"}],"wp:attachment":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media?parent=2665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/categories?post=2665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/tags?post=2665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}