{"id":2607,"date":"2015-05-05T11:49:57","date_gmt":"2015-05-05T10:49:57","guid":{"rendered":"http:\/\/www.dial-a-molecule.org\/wp\/?p=2607"},"modified":"2015-05-05T11:49:57","modified_gmt":"2015-05-05T10:49:57","slug":"closed-loop-optimisation-of-synthesis-meeting-report","status":"publish","type":"post","link":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/closed-loop-optimisation-of-synthesis-meeting-report\/","title":{"rendered":"Closed Loop Optimisation of Synthesis: Meeting Report"},"content":{"rendered":"

Closed Loop Optimisation of Synthesis<\/span><\/h3>\n

GSK, Stevenage, 16th April 2015<\/span><\/h4>\n
Organisers:\u00a0 Prof Richard Whitby, Dr Robin Attrill, Mr Andrew Richards and Dr Gill Smith<\/h5>\n

\u00a0\u201cClosed Loop Optimisation of Synthesis<\/strong>\u201d was a very successful one-day symposium organised by the EPSRC Dial-a-Molecule Grand Challenge Network, and held at GSK\u2019s Stevenage site.\u00a0 The meeting was designed to bring together researchers from chemistry and beyond, with both academic and industrial backgrounds, to discuss the state of the art and new developments in the field of closed loop optimisation.<\/p>\n

\u00a0The day began with a welcome from Dr Robin Attrill (GSK)<\/em> and was followed by Andy Richards (GSK)<\/em> who described the benefits of closed loop methodologies when developing chemical processes, and identified opportunities for their application within the pharmaceutical industry.\u00a0 The first session concluded with a plenary presentation from Dr Richard Bourne (University of Leeds)<\/em> who outlined the work his group is involved with in automated optimisation in continuous flow reactors, utilising Design of Experiments, Simplex, Snobfit and other algorithms together with appropriate on-line analysis, such as quantitative MS. <\/p>\n

The second session featured short talks from the Dial-a-Molecule inspired \u201cClosed Loop Optimisation for Sustainable Chemical Manufacture\u201d project team.\u00a0 Prof Richard Whitby (University of Southampton), Prof Dave Woods (University of Southampton) Dr Alison Nordon (University of Southampton) and Prof Alexei Lapkin (University of Cambridge)<\/em> discussed the ongoing collaborative efforts towards enabling the development and operation of new, agile, more cost effective and sustainable chemical manufacturing processes.\u00a0 Flash poster presentations concluded the morning session.<\/p>\n

Following the lunch break, Prof Martyn Poliakoff (University of Nottingham)<\/em> delivered a most entertaining plenary lecture describing work carried out at Nottingham around self-optimising reactions using on-line IR.\u00a0 Chris Selway (Cyclofluidic Ltd)<\/em> then spoke about closed loop optimisation using non-linear regression analysis applied to drug discovery, with future application to synthesis and the session drew to a close with Dr Ewan Mercer (Perceptive Engineering)<\/em> presenting the results of collaborative efforts towards the control of novel continuous crystallisation reactors for flexible manufacturing.\u00a0 <\/p>\n

Dr Frank Langbein (Cardiff University)<\/em> opened the final session of the day with his talk on the optimal control of chemical reactions at the quantum level with data-driven models, and was followed by Prof Lee Cronin (University of Glasgow)<\/em> who spoke about research his group is carrying out on using configurable robotics, algorithms and randomness to discover and synthesise new molecules by breaking the current synthetic methodology paradigm.\u00a0 The formal part of the day concluded with all speakers involved in a panel discussion that debated some of the merits of closed loop optimisation.\u00a0 Some animated discussions continued during the closing reception.<\/p>\n

Approximately 100 delegates attended the one day meeting, making it one of the most popular theme meetings that Dial-a-Molecule have run.\u00a0 Alongside the scientific program, the day featured a lively exhibition<\/strong> from leading technology suppliers: Advion, Amigo-Chem, Cambridge Reactor Designs, Gilson, HEL Group, JMP, Mettler-Toledo, Radleys, Syrris, Uniqsis and Vapourtec<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0<\/span>\u201c<\/span>Closed Loop Optimisation of Synthesis<\/strong>\u201d was held at GSK\u2019s Stevenage site on 16 April 2015.\u00a0 The meeting was designed to bring together researchers from chemistry and beyond, with both academic and industrial backgrounds, to discuss the state of the art and new developments in the field of closed loop optimisation. \u00a0Find the meeting report here.<\/span><\/p>

Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":2475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7],"tags":[40,47,48,52],"class_list":["post-2607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-2","tag-events","tag-meeting-report","tag-meetings","tag-news","nodate","item-wrap"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?fit=275%2C139&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p6CjJ1-G3","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/comments?post=2607"}],"version-history":[{"count":0,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2607\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media\/2475"}],"wp:attachment":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media?parent=2607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/categories?post=2607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/tags?post=2607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}