{"id":2484,"date":"2014-11-28T15:08:01","date_gmt":"2014-11-28T15:08:01","guid":{"rendered":"http:\/\/www.dial-a-molecule.org\/wp\/?p=2484"},"modified":"2015-10-26T11:47:40","modified_gmt":"2015-10-26T11:47:40","slug":"upcoming-event-closed-loop-optimisation-of-synthesis","status":"publish","type":"post","link":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/upcoming-event-closed-loop-optimisation-of-synthesis\/","title":{"rendered":"Closed Loop Optimisation of Synthesis"},"content":{"rendered":"<h2 style=\"text-align: center\"><strong><span style=\"color: #0000ff\">Closed Loop Optimisation of Synthesis<\/span><\/strong><\/h2>\n<h5 style=\"text-align: center\">16 April 2015<br \/>\nat<br \/>\nGSK Stevenage<\/h5>\n<p>The optimisation of of synthetic procedures is a time-consuming process which is rarely carried out as efficiently as would be desirable. Automated reaction equipment, and in-line\/in-situ analytical tools are becoming more readily available, but these still require the chemist to set-up reactions, analyse the outcomes, and decide which experiment(s) to do next.<\/p>\n<p>In addition to keynote presentations, the day will also include:<\/p>\n<ul>\n<li>progress from the Dial-a-Molecule inspired &#8220;Manufacturing the Future &#8211; Closed Loop Optimisation&#8221; team<\/li>\n<li>the opportunity to showcase your own research in an interactive flash poster session<\/li>\n<li>an exhibition from key suppliers<\/li>\n<li>a lively panel discussion to debate the merits of Closed Loop Optimisation<\/li>\n<\/ul>\n<p><strong><span style=\"color: #3366ff\">Meeting report<\/span>:<\/strong>\u00a0Download <a href=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO-report.pdf\">here<\/a><\/p>\n<p><span style=\"color: #3366ff\"><strong>Program<\/strong><\/span>: Also available as a <a href=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLOprogram_final.pdf\">PDF download here<\/a><\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>09:00<\/strong><\/td>\n<td><strong>Registration and coffee<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>09:30<\/strong><\/td>\n<td><strong>Welcome and Introduction<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Dr Robin Attrill (GSK)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>09:45<\/strong><\/td>\n<td><strong>Opportunities for closed loop optimisation with the pharmaceutical industry<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Mr Andrew Richards (GSK)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>10:05<\/strong><\/td>\n<td><strong>Automated optimisation in continuous flow<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Dr Richard Bourne (University of Leeds)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>10:50<\/strong><\/td>\n<td><strong>Coffee and exhibition<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>11:10<\/strong><\/td>\n<td><strong>Manufacturing the future: Closed loop optimisation for sustainable chemical manufacture<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td>Closed loop optimisation of continuous processes using HPLC Monitoring;<em> Prof Richard Whitby (University of Southampton<\/em>Sequential optimisation of semi-batch reactions for discovery of process recipes; P<em>rof Alexei Lapkin (University of Cambridge)<\/em><\/p>\n<p>Multivariate analysis of reaction data; <em>Dr Alison Nordon (University of Strathclyde)<\/em><\/p>\n<p>Statistical challenges for automatic experimentation; <em>Prof Dave Woods (University of Southampton)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>12:15<\/strong><\/td>\n<td><strong>Flash poster presentations<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>12:45<\/strong><\/td>\n<td><strong>Lunch, exhibition and poster session<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>13:45<\/strong><\/td>\n<td><strong>Self-optimising and other reactions<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Prof Martyn Poliakoff (University of Nottingham)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>14:30<\/strong><\/td>\n<td><strong>Closed loop optimisation using non-linear regression analysis<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Mr Chris Selway (Cyclofluidic)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>14:50<\/strong><\/td>\n<td><strong>Control of novel continuous reactors in flexible manufacturing<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Dr Ewan Mercer (Perceptive Engineering)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>15:10<\/strong><\/td>\n<td><strong>Afternoon refreshments and exhibition<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>15:30<\/strong><\/td>\n<td><strong>Optimal control of chemical reactions with data-driven models<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Dr Frank Langbein (Cardiff University)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>15:50<\/strong><\/td>\n<td><strong>Using configurable robotics, algorithms and randomness to discover and synthesise new molecules<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Prof Lee Cronin (Univerisity of Glasgow)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>16:35<\/strong><\/td>\n<td><strong>Panel discussion<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>17:15<\/strong><\/td>\n<td><strong>Poster session and wine reception<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left\"><span style=\"color: #3366ff\"><strong>Exhibiting Companies<\/strong><\/span>: \u00a0Advion, Amigo Chem, Cambridge Reactor Design, Gilson, HEL Group, JMP, Mettler Toledo, Radleys, Syrris, Uniqsis, Vaprourtec<\/p>\n<p style=\"text-align: left\"><span style=\"color: #0000ff\"><strong><span style=\"color: #3366ff\">Organising Committee<\/span>:<\/strong><\/span> \u00a0Richard Whitby, Robin Attrill, Andrew Richards &amp; Gill Smith<\/p>\n<p style=\"text-align: left\">\n<p style=\"text-align: left\"><a href=\"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"2475\" data-permalink=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/phases-i-ii\/events\/clo\/\" data-orig-file=\"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?fit=275%2C139&amp;ssl=1\" data-orig-size=\"275,139\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"CLO\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?fit=275%2C139&amp;ssl=1\" class=\"aligncenter wp-image-2475 size-full\" src=\"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?resize=275%2C139\" alt=\"CLO\" width=\"275\" height=\"139\" srcset=\"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?w=275&amp;ssl=1 275w, https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?resize=200%2C101&amp;ssl=1 200w\" sizes=\"auto, (max-width: 275px) 100vw, 275px\" \/><\/a><a title=\"Closed Loop Optimisation of Synthesis\" href=\"http:\/\/www.dial-a-molecule.org\/wp\/events-listing\/closed-loop-optimisation-of-synthesis\/\"><br \/>\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"color: #489ed5\"><strong>April 2015, GSK Stevenage<\/strong><\/span><br \/>\nA discussion on how to &#8216;Close the Loop&#8217; and utilise computer algorithms and automated\u00a0equipment to remove the drudgery from optimising synthetic procedures<\/p><p><a class=\"more-link btn\" href=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/upcoming-event-closed-loop-optimisation-of-synthesis\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":2475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8],"tags":[48,61],"class_list":["post-2484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phase_1_2-events","tag-meetings","tag-smart-lab","nodate","item-wrap"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2014\/11\/CLO.png?fit=275%2C139&ssl=1","jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p6CjJ1-E4","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/comments?post=2484"}],"version-history":[{"count":3,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2484\/revisions"}],"predecessor-version":[{"id":3107,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/2484\/revisions\/3107"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media\/2475"}],"wp:attachment":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media?parent=2484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/categories?post=2484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/tags?post=2484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}