{"id":1279,"date":"2013-02-04T22:39:13","date_gmt":"2013-02-04T22:39:13","guid":{"rendered":"http:\/\/www.dial-a-molecule.org\/wp\/?p=1279"},"modified":"2015-10-26T15:11:27","modified_gmt":"2015-10-26T15:11:27","slug":"drug-discovery-leveraging-academic-impact-through-novel-fragments","status":"publish","type":"post","link":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/drug-discovery-leveraging-academic-impact-through-novel-fragments\/","title":{"rendered":"Drug Discovery: Leveraging Academic Impact Through Novel Fragments"},"content":{"rendered":"<h3><\/h3>\n<table style=\"width: 660px;height: 172px\" border=\"0\">\n<tbody>\n<tr>\n<td>\n<h3><a href=\"http:\/\/www.3dfrag.org\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-1485 aligncenter\" style=\"margin: 10px 30px\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3DFragCons-logo.png\" alt=\"3DFragCons-logo\" width=\"156\" height=\"83\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3DFragCons-logo.png 994w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3DFragCons-logo-300x161.png 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3DFragCons-logo-200x107.png 200w\" sizes=\"auto, (max-width: 156px) 100vw, 156px\" \/><\/a><\/h3>\n<\/td>\n<td>\n<h3><a href=\"http:\/\/royalsociety.org\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-1483 aligncenter\" style=\"margin-left: 50px;margin-right: 50px\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/RS-logo-stacked_black_A4.jpg\" alt=\"RS_Logotype_Black\" width=\"180\" height=\"121\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/RS-logo-stacked_black_A4.jpg 638w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/RS-logo-stacked_black_A4-300x204.jpg 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/RS-logo-stacked_black_A4-200x136.jpg 200w\" sizes=\"auto, (max-width: 180px) 100vw, 180px\" \/><\/a><\/h3>\n<\/td>\n<td>\n<h3><a href=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/UniHudd-logo.png\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-1488 aligncenter\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/UniHudd-logo.png\" alt=\"UniHudd-logo\" width=\"159\" height=\"103\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/UniHudd-logo.png 741w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/UniHudd-logo-300x192.png 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/UniHudd-logo-200x128.png 200w\" sizes=\"auto, (max-width: 159px) 100vw, 159px\" \/><\/a><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>A Dial-a-Molecule EPSRC Grand Challenge theme event<\/h3>\n<p><em><strong> When:<\/strong> 5 February 2013<\/em><br \/>\n<em><strong>Where:<\/strong> 3M Buckley Innovation Centre, University of Huddersfield (http:\/\/www.3mbic.com\/)<\/em><\/p>\n<p>The last 10 years have seen a radical restructuring of global pharma R&amp;D in response to the increasingly challenging process of discovering, progressing and launching a new drug. A consequence of this business remodelling has been the tapering of UK synthetic and medicinal chemistry capacity; this offers an opportunity for academic synthetic chemists to generate impact in the drug discovery process, especially in the hit\/lead identification phase of the drug pipeline. The 3D Fragment Consortium is an EPSRC-funded network, which aims to expand the chemical space of drug discovery by leveraging novel class-leading academic synthetic chemistry. Access to such cutting-edge synthetic expertise will empower and enable the study of drug target classes previously lacking high quality chemical start points; such as protein-protein interactions. Given the UK strength in chemical synthesis, a chemical consortium focused upon the implementation of powerful synthetic methods would be perfectly placed to design and deliver novel three-dimensional chemical libraries for fragment screening to complement existing fragment libraries. The consortium would also be able to contribute to the generation of useful chemical start points for a broad range of target therapeutic classes.<\/p>\n<p>As part of the <strong>Royal Socie<\/strong><strong>ty Year of Science and Indu<\/strong><strong>stry<\/strong>, and in collaboration with the <strong>\u2018Dial-a-Molecule\u2019 EPSRC Grand Challenge Network<\/strong> and <strong>SMSDrug.net<\/strong>, on 5 February 2013 the <strong>3D Fragment Consortium<\/strong> will host a workshop meeting at which the opportunities and benefits for academic synthetic chemists will be presented. In particular, the workshop will discuss:<br \/>\n\u2022\u00a0\u00a0 \u00a0how class-leading academic synthesis can be used in a drug discovery context<br \/>\n\u2022\u00a0\u00a0 \u00a0the key features of fragment libraries, and their relevance to cutting-edge research groups<br \/>\n\u2022\u00a0\u00a0 \u00a0the tools available to enable synthetic chemists to make contributions to the drug discovery process<br \/>\n\u2022\u00a0\u00a0 \u00a0constructing an inclusive network of med chem-facing academic chemists<br \/>\n\u2022\u00a0\u00a0 \u00a0funding possibilities<br \/>\n\u2022\u00a0\u00a0 \u00a0how to deal with IP issues<\/p>\n<p>The key deliverable of the event will be the creation of a blueprint for successful collaborations between academic chemists and drug-hunting organisations.<\/p>\n<p><span style=\"color: #3366ff\"><strong>Program:<\/strong><\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>10:00<\/strong><\/td>\n<td><strong>Registration<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>10:30<\/strong><\/td>\n<td><strong>Opening remarks<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><em>Joe Sweeney &amp; Andy Morley<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>10:40<\/strong><\/td>\n<td><strong>Lecture 1:<\/strong> <em>Dr Stuart Conway (University of Oxford)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>11:00<\/strong><\/td>\n<td><strong>Lecture 2: <\/strong><em>Prof Greg Challis (University of Warwick)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>11:20<\/strong><\/td>\n<td><strong>Lecture 3:<\/strong> <em>Dr Paul Brennan (Structural Genomics Consortium)<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>12:15<\/strong><\/td>\n<td><strong>Lunch<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>13:30<\/strong><\/td>\n<td><strong>Discussion session 1: 1000 Click Reactions<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>14:15<\/strong><\/td>\n<td><strong>Discussion session 2: Create scaffold diversity using academic research<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>15:00<\/strong><\/td>\n<td><strong>Tea\/coffee<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>15:30<\/strong><\/td>\n<td><strong>Discussion session 3: Tools to enable academics to contribute to drug discovery<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>16:15<\/strong><\/td>\n<td><strong>Discussion forum: IP issues<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>16:30<\/strong><\/td>\n<td><strong>Conclusions and close of meeting<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<table style=\"height: 124px\" border=\"0\" width=\"660\">\n<tbody>\n<tr>\n<td><a href=\"http:\/\/www.smsdrug.net\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-1486 aligncenter\" style=\"margin-left: 30px;margin-right: 30px\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/SMSDrugNet-logo.png\" alt=\"SMSDrugNet-logo\" width=\"216\" height=\"69\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/SMSDrugNet-logo.png 433w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/SMSDrugNet-logo-300x96.png 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/SMSDrugNet-logo-200x64.png 200w\" sizes=\"auto, (max-width: 216px) 100vw, 216px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/www.3mbic.com\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"  wp-image-1487 aligncenter\" style=\"margin-left: 40px;margin-right: 40px\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3MBIC-logo.png\" alt=\"3MBIC-logo\" width=\"164\" height=\"85\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3MBIC-logo.png 683w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3MBIC-logo-300x155.png 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/3MBIC-logo-200x104.png 200w\" sizes=\"auto, (max-width: 164px) 100vw, 164px\" \/><\/a><\/td>\n<td><a href=\"http:\/\/www.dial-a-molecule.org\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-1484 aligncenter\" style=\"margin-left: 20px;margin-right: 20px\" src=\"http:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/DaM-logo.png\" alt=\"DaM-logo\" width=\"137\" height=\"87\" srcset=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/DaM-logo.png 761w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/DaM-logo-300x193.png 300w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/DaM-logo-200x129.png 200w, https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-content\/blogs.dir\/sites\/50\/2013\/02\/DaM-logo-80x50.png 80w\" sizes=\"auto, (max-width: 137px) 100vw, 137px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"color: #489ed5\"><strong>February 2013, University of Huddersfield\u00a0<\/strong><\/span><br \/>\nA theme event held in collaboration with SMSdrug.net and the 3D Fragment Consortium<\/p><p><a class=\"more-link btn\" href=\"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/drug-discovery-leveraging-academic-impact-through-novel-fragments\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":1494,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[19,26,34,40],"class_list":["post-1279","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phase_1_2-events","tag-3d-fragments","tag-consortium","tag-drug-discovery","tag-events","nodate","item-wrap"],"_links":{"self":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/1279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/comments?post=1279"}],"version-history":[{"count":3,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/1279\/revisions"}],"predecessor-version":[{"id":3119,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/posts\/1279\/revisions\/3119"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media\/1494"}],"wp:attachment":[{"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/media?parent=1279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/categories?post=1279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/generic.wordpress.soton.ac.uk\/dial-a-molecule\/wp-json\/wp\/v2\/tags?post=1279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}