We work with Mariana Vargas-Caballero‘s group to better understand the cellular and molecular mechanisms underlying neuronal plasticity in health and disease, with a particular focus on early tauopathy and mild cognitive impairment.
In collaboration with Yihua Wang, we investigate how stable post-translational modifications modulate neuronal excitability and network synchronicity.
Related publications:
Pegasiou CM, Zolnourian A, Gomez-Nicola D, Deinhardt, K, Nicoll JAR, Ahmed A, Vajramani G, Grundy P, Verhoog, MB, Mansvelder, HD, Perry VH, Bulters D, Vargas-Caballero M: Age dependent changes in synaptic NMDA receptor composition in adult human cortical neurons. Cereb Cortex. 2020 Mar 17:bhaa052.
Hallinan GI, Vargas-Caballero M, West J, Deinhardt K: Tau misfolding efficiently propagates between individual intact hippocampal neurons. JNeurosci. 2019 Nov 27;39(48):9623-9632
Warming H, Pegasiou CM, Pitera AP, Kariis H, Houghton SD, Kurbatskaya K, Ahmed A, Grundy P, Vajramani V, Bulters D, Altafaj X, Deinhardt K, Vargas-Caballero M: A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain. Mol Brain. 2019 Jul 4;12(1):64
Sri S, Pegasiou CM, Cave CA, Hough K, Wood N, Gomez-Nicola D, Deinhardt K, Bannerman D, Perry V & Vargas-Caballero M: Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease. Acta Neuropathol Commun 2019 Feb 22;7(1):25