The CHIEF study is done in collaboration with the Manchester Paediatric and Adolescent Cochlear Implant Programme team.

About the CHIEF study

We are investigating how well people hear with their cochlear implant.

Many people benefit greatly from their implant but there are a few people do not have a positive experience. Why this happens is unknown.

We are investigating how cells inside the cochlea (inner ear) respond to the implant. Other research has shown that how cells respond to the implant (the cellular response) differs between people. What causes the difference is not clear. We do not know if or how this links with how well someone does with their cochlear implant. Each immune system is exposed to different things across time. We think this might affect the immune state of tissues in the body, including in the ear.

In this study, we want to investigate the inflammatory state of the middle and inner ear to see if this affects how well a person does with their cochlear implant.

Study aim

To identify differences in inflammation in the ear between children and young people at the time they undergo cochlear implantation.

Who is eligible to take part?

We are inviting children and young people, 16 or younger and eligible for a cochlear implant at Manchester University NHS Foundation Trust.

Information about the study will be given to children and young people, as well as parents and guardians, during the information session that is part of the cochlear implant assessment pathway. The implanting surgeon will talk through the study in more detail and discus the participant information sheet. This will be a good opportunity to ask any questions you have. If you and your parent(s)/guardian(s) are happy for you to take part – you will provide consent and be recruited into the study.

Study design

If you have any questions about the study, please contact Kate Hough.